Table 2.
Profile of downregulated genes in pancreatic tumors of mice treated with fucoxanthin (Fx) 1.
| Gene Symbol | Description | Fold Change 2 | p-Value 3 |
|---|---|---|---|
| Prss3 | Protease, serine 3 | −8.03 | 0.0439 |
| Klk1b5 | Kallikrein 1-related peptidase b5 | −6.31 | 0.0491 |
| Gc | Group specific component | −5.52 | 0.0169 |
| Klk1b4 | Kallikrein 1-related peptidase b4 | −5.36 | 0.0476 |
| Ccl21a 4 | Chemokine (C-C motif) ligand 21A (serine) | −3.98 | 0.0493 |
| Mmrn1 | Multimerin 1 | −2.99 | 0.0329 |
| Dpt | Dermatopontin | −2.71 | 0.0464 |
| Bank1 | B cell scaffold protein with ankyrin repeats 1 | −2.57 | 0.0092 |
| Xlr4b | X-linked lymphocyte-regulated 4B | −2.54 | 0.0193 |
| Gkn3 | Gastrokine 3 | −2.53 | 0.014 |
| Tbx1 | T-box 1 | −2.49 | 0.0094 |
| Cd209f | CD209f antigen | −2.43 | 0.0338 |
| Epha7 | Eph receptor A7 | −2.34 | 0.0014 |
| Slc30a8 | Solute carrier family 30 (zinc transporter), member 8 | −2.29 | 0.0349 |
| Cd19 | CD19 antigen | −2.27 | 0.0107 |
| Egflam | EGF-like, fibronectin type III and laminin G domains | −2.26 | 0.0008 |
| Btla | B and T lymphocyte attenuator | −2.15 | 0.014 |
| 5330417C22Rik | RIKEN cDNA 5330417C22 gene | −2.11 | 0.0003 |
| Kmo | Kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) | −2.09 | 0.025 |
| Klk1b8 | Kallikrein 1-related peptidase b8 | −2.09 | 0.025 |
| Cpn1 | Carboxypeptidase N, polypeptide 1 | −2.09 | 0.0246 |
| Vtn | Vitronectin | −2.07 | 0.0409 |
| Efcab3 | EF-hand calcium binding domain 3 | −2.06 | 0.0237 |
| Klk1b3 | Kallikrein 1-related peptidase b3 | −2.06 | 0.011 |
| Triqk | Triple QxxK/R motif containing | −2.05 | 0.0077 |
| Ntrk2 | Neurotrophic tyrosine kinase, receptor, type 2 | −2.00 | 0.0052 |
1 Among all 88 downregulated genes significantly altered, 26 downregulated genes with ≥2.0-fold change were shown. 2 Fold change in gene expression in pancreatic tumors of mice with Fx administration (group 1) compared to that of control mice (group 2). 3 Significant differences between groups 1 and 2 by an exact test on edge R. 4 Genes colored gray were the genes that were examined for protein expression as significant cancer-related molecules (Figure 6A,B).