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Comparison of the X-ray information about the JNJ-53718678 highly related analogues JNJ-49153390 (PDB code = 5EA4) [13], JNJ-36689282 (PDB code = 6VKD) [36], JNJ-36811054 (PDB code = 6VKC) [36], and RV521 (PDB code = 7KQD) [28] with the reference JNJ-53718678 (PDB code = 5KWW) [27]. The most recurrent conserved moieties and bioisostere substitutions are highlighted by light-blue circles and dot lines.
