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Gener et al. developed and synthesized polymeric micelles loaded with Zileuton™, a potent inhibitor of ALOX5 in cancer stem cells (CSCs), which were chosen as a therapeutic target candidate based on high-throughput screening data. Its great potential for CSC treatment was subsequently demonstrated in vitro and in vivo in breast CSC fluorescent models. PM-Zileuton™ shows strong reduction in the amount of intratumoral CSCs and, further, of blood circulating CSCs in vivo [82].
