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Mechanisms of action of pesticides on Sertoli cells. Exposure to pesticides leads to elevated amounts of ROS that contribute to mitochondrial damages and endoplasmic reticulum stress, as well as to Sertoli cells´ apoptosis, thus disrupting the BTB and inducing germ cells´ apoptosis. Abbreviations correspond to: ROS—reactive oxygen species; OS—oxidative stress; ER—endoplasmic reticulum; BTB—blood-testis-barrier.
