ACL |
anterior cruciate ligament |
ADAMTS |
a disintegrin and metalloproteinase with thrombospondin motifs |
AFM |
atomic force microscopy |
BGN |
biglycan |
COMP |
cartilage oligomeric protein |
COX-2 |
cyclooxygenase-2 |
CRTC1/2 |
CREB-regulated transcription coactivator 1 |
CTGF |
connective tissue growth factor |
CTS |
cyclic tensile strain |
DAMPs |
damage-associated molecular pattern |
DCN |
decorin |
DMM |
destabilisation of the medial meniscus |
ECM |
extracellular matrix |
FGF |
fibroblast growth factor |
FN |
fibronectin |
GAG |
glycosaminoglycan |
HDGF |
hepatoma-derived growth factor |
HSPG2 |
heparan sulphate proteoglycan 2 |
IGF1 |
insulin growth factor 1 |
Ihh |
Indian Hedgehog |
IL |
interleukin |
LINC |
linker of nucleoskeleton and cytoskeleton |
LRP6 |
lipoprotein receptor-related protein 6 |
ITM |
interterritorial matrix |
MAPK |
mitogen-activated protein kinase |
MMP |
matrix metalloproteinase |
NG2 |
neural/glial antigen 2 |
OA |
osteoarthritis |
PCM |
pericellular matrix |
PDGF |
platelet-derived growth factor |
PG |
proteoglycan |
PGE2
|
prostaglandin E2
|
PRG4 |
proteoglycan 4 |
P-SHG |
polarisation sensitive second harmonic generation |
PTOA |
post-traumatic osteoarthritis |
sGAG |
sulphated glycosaminoglycan |
SLRP |
small leucine-rich proteoglycan |
SZ |
superficial zone |
TAL |
tibial axial loading |
TAZ |
transcriptional co-activator with PDZ-binding motif |
TGF |
transforming growth factor |
TLRs |
Toll-like receptors |
TM |
territorial matrix |
TNFα |
tumour necrosis factor alpha |
TRPV |
transient receptor potential vanilloid |
YAP |
Yes-associated protein |