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. 2021 Dec 18;22(24):13592. doi: 10.3390/ijms222413592

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Inhibition of the cell entry of vesicular stomatitis virus G (VSV.G) pseudotyped particles. The 293 T cells transiently expressing human ACE2 and TMPRSS2a were pre-treated with the selected compounds at 10 µM for 3 h before they were inoculated with VSV.G envelope protein pseudotyped lentivirus particles. At 48 h postinoculation, pseudotype virus entry was analyzed by luminescence readout (normalization against untreated VSV.G virus entry). Data represent the mean ± SEM from three independent experiments carried out in technical triplicates. Unpaired two-tailed t-test analysis was used to calculate statistical significance (p > 0.05 (ns), p < 0.001 (***) compared to untreated spike virus entry). Concentrations are displayed in logarithmic scale and molar concentrations. The logarithmic scale is used for better visibility of the wide range of concentrations that are used in these assays.