Figure 1.

Neutralization of variant SARS-CoV-2 pseudoviruses by convalescent sera. The neutralization titers represented as 50% inhibitory concentrations (IC₅₀) against pseudoviruses bearing spike proteins from the indicated variants are plotted. (A) Individual neutralization titers of convalescent sera are presented. Blue dots: sera from subjects infected with variants containing L452R in spike. Black dots: sera from subjects infected with WT(D614G) variants. (B) The neutralization titers of individuals infected with WT(D614G) SARS-CoV-2. (C) The neutralization titers of individuals infected with SARS-CoV-2 bearing L452R in spike. The numbers over each graph indicate the GMT. The numbers in parentheses are the ratios of WT(D614G) GMT/individual variant GMT. p values were calculated by one-way analysis of variance (ANOVA) with Dunnett’s multiple comparisons tests (variants compared to WT(D614G)). Titers measuring below the lowest serum dilution of 1:40 were treated as 20 for statistical analysis. All neutralization titers were log₂ transformed before test. Bars: geometric means of titers (GMT) with %95 CI. *: p ≤ 0.05; **: p ≤ 0.01; ***: p ≤ 0.001; ****: p ≤ 0.0001.