Figure 2.

Neutralization of variant SARS-CoV-2 pseudoviruses by vaccine-elicited sera. The neutralization titers represented as 50% inhibitory concentrations (IC₅₀) against pseudoviruses bearing spike proteins from the indicated variants are plotted. (A) Neutralization titers of Pfizer/BioNtech BNT162b2 vaccination sera are presented. (B) Neutralization titers of Moderna mRNA-1273 vaccination sera are presented. Bars: geometric means of titers (GMT) with 95% CI. The numbers over each graph indicate the GMT. The numbers in parentheses are the ratios of WT(D614G) GMT/individual variant GMT. p values were calculated by one-way analysis of variance (ANOVA) with Dunnett’s multiple comparisons tests (variants compared to WT(D614G)). Titers measuring below the lowest serum dilution of 1:40 were treated as 20 for statistical analysis. All neutralization titers were log₂ transformed before test. *: p ≤ 0.05; **: p ≤ 0.01; ****: p ≤ 0.0001.