Table 2.
Clinical Trials.
| Bacterial Strain | Type of Cancer | Clinical Phase | Identifier No. | Reference (All Links Were Accessed on 16 December 2021) |
|---|---|---|---|---|
| C. histolyticum | Lipoma | I | NCT01613313 | https://clinicaltrials.gov/ct2/show/NCT01613313 |
| Lipoma | I | NCT02249052 | https://clinicaltrials.gov/ct2/show/NCT02249052 | |
| C. butyricum M55 | Vascular glioblastoma | I | - | [190] |
| C. novyi-NT | Solid tumor malignancies | I | NCT01924689 | [173] |
| Colorectal cancer | I | NCT00358397 | https://clinicaltrials.gov/ct2/show/NCT00358397 | |
| Solid tumor malignancies | I | NCT01118819 | https://clinicaltrials.gov/ct2/show/NCT01118819 | |
| Refractory advanced solid tumors | Ib | NCT03435952 | https://clinicaltrials.gov/ct2/show/NCT03435952 | |
| L. monocytogenes | Cervical cancer | II | - | [191] |
| Cervical cancer | III | NCT02853604 | https://clinicaltrials.gov/ct2/show/NCT02853604 | |
| Metastatic pancreatic tumors | II | - | [192] | |
| Malignant epithelial mesothelioma Adenocarcinoma of the pancreas, Non-small cell lung adenocarcinoma of the ovaries | I | NCT00585845 | https://clinicaltrials.gov/ct2/show/NCT00585845 | |
| HPV-16 +ve oropharyngeal carcinoma | I | NCT01598792 | https://clinicaltrials.gov/ct2/show/NCT01598792 | |
| L. monocytogenes (LADD) | Prostatic neoplasms (castration resistant) | II | NCT01613313 | https://clinicaltrials.gov/ct2/show/NCT02625857 |
| Non-small cell lung carcinoma | I | NCT02592967 | https://clinicaltrials.gov/ct2/show/NCT02592967 | |
| S. typhimurium (χ4550) | Hepatocellular carcinoma | I | - | [193] |
| S. typhimurium VNP20009 | Metastatic melanoma, metastatic renal cell carcinoma | I | - | [15] |
| S. typhimurium VNP20009 | Melanoma | I | - | [17] |
| S. typhimurium VNP20009 expressing TAPET-CD (cytosine deaminase) | Head and neck, and esophageal adenocarcinoma | I | - | [[18]] |
| S. typhimurium VNP20009 | Advanced metastatic solid tumors | I | NCT00004216 | https://clinicaltrials.gov/ct2/show/NCT00004216 |
| Solid tumors | I | NCT00006254 | https://clinicaltrials.gov/ct2/show/NCT00006254 | |
| Neoplasm metastatic tumor | I | NCT00004988 | https://clinicaltrials.gov/ct2/show/NCT00004988 | |
| S. typhimurium expressing IL-2 | Liver cancer | I | NCT01099631 | https://clinicaltrials.gov/ct2/show/NCT01099631 |
| S. typhimurium Ty21a VXM01 | Pancreatic cancer | I | - | [194] |
| Mixed Bacterial Vaccine | Malignant tumors | I | NCT00623831 | https://clinicaltrials.gov/ct2/show/NCT00623831 |