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. 2021 Dec 18;22(24):13599. doi: 10.3390/ijms222413599

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of magnesium (Mg²⁺) on the antinociceptive activity of morphine (MRF) on the 1st day (Panel A) and the 7th day (Panel B) of the drugs’ application in streptozotocin (STZ)-induced diabetic neuropathic pain. Nociceptive thresholds, expressed in grams, were measured before STZ administration (baseline) and then before (0) and after tested substances administration in rats with STZ-induced diabetic neuropathic pain for 2 h. Data are presented as means ± SEM. Statistical analysis was performed by two-way ANOVA followed by Bonferroni’s post-hoc test. *** p < 0.001 (STZ + Mg²⁺ + MRF vs. STZ), ### p < 0.001, ## p < 0.01, # p < 0.05 (STZ + Mg²⁺ + MRF vs. STZ + MRF), $$ p < 0.01, $ p < 0.05 (STZ + Mg²⁺ vs. STZ), & p < 0.05 (STZ + MRF vs. STZ); n = 6 rats for each group.