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. 2021 Dec 10;22(24):13306. doi: 10.3390/ijms222413306

Figure 8.

Figure 8

Model of the regulation of p53 expression with the involvement of PCBP2 interacting with the 5′ and 3′ ends of p53 mRNA. Under normal conditions, PCBP2 increases the stability of p53 mRNA, probably via the interactions with the 3′UTR, while in the presence of stress factors PCBP2 binds to the 5′ terminus of p53 mRNA modulating p53 translation. PCBP2 is likely to bind to both ends of p53 mRNA simultaneously under stress conditions, which resembles the interactions with viral RNAs (grey box).