Canonical Pathway
|
p Value
|
Molecules
|
Role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza |
2.51 × 10−12
|
CXCL10, DDX58, EIF2AK2, IFIT2, IFIT3, IRF7, ISG15, MX1, OAS2, RSAD2
|
Interferon signaling |
1.29 × 10−10
|
IFI6, IFIT1, IFIT3, IFITM1, IFITM2, ISG15, MX1
|
Role of pattern recognition receptors in recognition of bacteria and viruses |
4.90 × 10−4
|
DDX58, EIF2AK2, IFIH1, IRF7, OAS2
|
Role of RIG1-like receptors in antiviral innate immunity |
9.33 × 10−4
|
DDX58, IFIH1, IRF7
|
WNT/β-catenin signaling |
5.89 × 10−3
|
CSNK2A1, MMP7, PPP2CB, TLE4
|
Sirtuin signaling pathway |
7.41 × 10−3
|
H1-3, MAPK7, SCNN1A, TIMM8A, WRN
|
Coronavirus replication pathway |
1.51 × 10−2
|
IFITM1, IFITM2
|
Role of PKR in interferon induction and antiviral response |
1.91 × 10−2
|
DDX58, EIF2AK2, IFIH1
|
Alveolar Mucosa Model (alv-ALI)
|
Canonical pathway
|
p Value
|
Molecules
|
p53 signaling |
4.07 × 10−3
|
BBC3, GNL3, TIGAR
|
APRIL (a proliferation-inducing ligand)-mediated signaling |
8.32 × 10−3
|
FOS, TNFSF13
|
Tight junction signaling |
2.04 × 10−2
|
CLDN11, FOS, MYH9
|
Integrin linked kinase signaling |
2.69 × 10−2
|
FOS, MYH9, RSU1
|
Agranulocyte adhesion, and diapedesis |
3.31 × 10−2
|
CLDN11, CXCL14, MYH9
|
Interleukin-1 signaling |
3.80 × 10−2
|
FOS, GNB4
|