Table 2.
Duodenal mucus- and epithelium-associated bacterial community variation.
| Univariate dbRDA | Mucus-Associated (Brush) | Epithelium-Associated (Biopsy) | ||||||
|---|---|---|---|---|---|---|---|---|
| F-Value | R2 (%) | p-Value | padj-Value | F-Value | R2 (%) | p-Value | padj-Value | |
| subject | 1.47 | 16 | 0.001 | 0.006 | 1.16 | 5.4 | 0.002 | 0.01 |
| group | 2.1 | 1.16 | 0.002 | 0.006 | 1.52 | 0.51 | 0.03 | 0.09 |
| PPI | 1.64 | 0.34 | <0.05 | 0.09 | 0.92 | 0 | 0.41 | 0.51 |
| gender | 1.02 | 0.01 | 0.38 | 0.38 | 1.05 | 0.03 | 0.4 | 0.4 |
| age | 1.16 | 0.09 | 0.23 | 0.28 | 1.47 | 0.25 | 0.06 | 0.12 |
| BMI | 1.52 | 0.28 | 0.07 | 0.1 | 1.05 | 0.03 | 0.32 | 0.4 |
Univariate distance-based redundancy analysis with individual effect sizes of subject (inter-individual variation), group, treatment and demographics, assuming covariate independence. Variables remaining significant after adjustment for multiplicity (Benjamini–Hochberg) were entered in a stepwise multivariate model for the mucus- and epithelium-associated microbiome variation.