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. 2021 Dec 20;22(24):13634. doi: 10.3390/ijms222413634

Figure 4.

Figure 4

Expression level of HRH1, HRH4, IL1R1, IL4R, NFκB, and COX-2 after 24 h of incubation with histamine alone and in mixtures with osthole (A) and fexofenadine (B). The horizontal line shows mean and the bars depict standard deviation. Statistically significant differences (Two-way ANOVA with Tukey’s multiple comparisons test) compared to control (cells cultured in medium; *—p < 0.05, ***—p < 0.001,****—p < 0.0001) and to cells treated with histamine (##—p < 0.01, ###—p < 0.001, ####—p < 0.0001) are marked; ns—non-significant. The analyzes were performed in triplicate in three independent experiments.