Figure 5.

Fecal microbiota transplantation from ovariectomized and sham mice to antibiotic-treated ovariectomized mice. Antibiotic-treated mice were ovariectomized and orally administered cecal luminal contents of sham and ovariectomized mice three times per week for four weeks. (A–F): Body weight, tibial bone mineral density (B–D), serum bone formation marker (E), and serum bone resorption marker (F) at sacrifice. (G,H): Relative mRNA expression of TNFα (G) and ZO-1 (H). N = 6–7 per group. BMD: bone mineral density, CTX: C-terminal telopeptide of collagen, LPS: lipopolysaccharide, PINP: procollagen type I N-terminal propeptide, TNFα: tumor necrosis factor alpha, ZO-1: zonula occludens-1.