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. 2021 Nov 25;13(12):4238. doi: 10.3390/nu13124238

Figure 14.

Figure 14

The surface model of the dimeric structure of ADH (green and cyan chains) visualizes two main tunnels (in the monomers of the dimeric structure of ADH) leading to the active site of ADH. The “bridge part” (consisting of residues Thr56, Leu57, Val58, Pro296, Asp297, and Ser298) above the large cavity forms a tunnel. The orange and purple arrows show the entrance for the coenzyme NAD+/NADH (stick model) and substrate, respectively. NAD+/NADH is visible from both tunnel entrances; the nicotinamide moiety interacts with the substrate entrance. Both chains are involved in the formation of the substrate tunnel.