Drug resistance mutation frequency in Mexico City, 2017–2020. Frequencies of surveillance drug resistance mutations (SDRMs) (a) and non-SDRMs (b) for the complete study period are shown, including a total of 6688 protease-reverse transcriptase and 6709 integrase sequences from unique individuals. Only resistance-associated mutations observed in the sequences are shown. All SDRMs and non-SDRMs defined in the Stanford HIV drug resistance database were analyzed. PI, protease inhibitors; NRTI, nucleoside reverse transcriptase inhibitors; NNRTI, non-nucleoside reverse transcriptase inhibitors; INSTI, integrase strand-transfer inhibitors.