Figure 1.

Layout of the human PKD1 gene, showing the location of three associated miRNA genes. The PKD1 transcription start site, and direction of transcription, is depicted by the black arrow located in exon one. Black boxes represent exons and dark grey bars are introns. Green boxes denote the location of CpG islands. miR-3180-5p is located upstream of exon one, miR-4516 is located in intron one and miR-1225 is found in intron 45. The PKD1 gene depiction is from the UCSC Genome Browser, human genome annotation Hg19.