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. 2021 Dec 3;13(12):2421. doi: 10.3390/v13122421

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Transmission electron microscopy of liver samples of p1-FA07 (Hepacivirus F)-infected animals (a–c) compared to a liver sample of a control animal (d), from experiment 4. Hepatocytes of infected bank voles show vesicular endoplasmic reticulum with organoid membranes (*), lipid droplet (LD) accumulation and pleomorphic lysosomal storage vesicles (arrows). Abbreviations: Gly: glycogen rosettes, LD: lipid droplet, M: mitochondria, Ncl: cell nucleus, rER: rough endoplasmic reticulum. Bar in each panel: 1 µm.