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G2 cell cycle arrest was detected in AXL inhibitor R428-treated parental SNU475 cell line. (A) Cell survival curve versus log R428 concentration (IC50 = 3.2 µM). (B) Cell cycle distribution of parental SNU475 cells versus increasing concentration of R428 at 24, 48, 72 h treatment. Sub-G1, G0/G1, S, G2/M, polyploid cells were colored in light orange, white, green, black, and orange, respectively.
