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. 2021 Dec 16;26(24):7643. doi: 10.3390/molecules26247643

Figure 10.

Figure 10

Hanging wire response (A), rotarod performance (B), and neurological score (C), analyzed mSOD1 transgenic and wild-type male mice at specific weeks during a chronic treatment from 63 day-old to 125 day-old with VCE-006.1 (20 mg/kg, daily and i.p.) or vehicle, and quantification of the number of Nissl-stained motor neurons (E), including representative images ((D); scale bar = 100 µm), in the lumbar ventral horn (marked with a dotted line) of the spinal cord in all experimental groups after the chronic treatment. Values are means ± SEM of more than 6 animals per group. Behavioral data were assessed by two-way ANOVA (with repeated measures), whereas Nissl staining data were assessed by one-way ANOVA, in both cases followed by the Tukey test (* p < 0.05, ** p < 0.01, *** p < 0.005 vs. wild-type mice; ## p < 0.01 vs. mSOD1 mice treated with vehicle).