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Inhibitory effects of compounds 3 and 4 on the level of PGE2 (A,D), IL-6 (B,E), and TNF-α (C,F) in BV2 and RAW264.7 cells. The cells were pretreated for 2 h with various concentrations of compounds 3 or 4 and stimulated for 24 h with lipopolysaccharide (LPS; 1 μg/mL). Error bars represent mean ± standard deviation of three independent experiments. * p < 0.05, ** p < 0.01 and *** p < 0.001 compared with the LPS-treated group.
