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Inhibitory effects of compounds 3 and 4 on nitrite production through the regulation of HO-1 activity in BV2 (A,C,E) and RAW264.7 (B,D,F) cells. The cells were treated with 50 μM of tin protoporphyrin-IX (SnPP) or compounds 3 or 4 and stimulated for 24 h with lipopolysaccharide (LPS; 1 μg/mL). Data are presented as mean ± standard deviation of three independent experiments. ** p < 0.01 and *** p < 0.001.
