. 2021 Dec 18;9(12):1500. doi: 10.3390/vaccines9121500

Table 3.

Median percentage change in Ab titers from 3 months to 6 months (N = 365).

Variable	Percentage Change in Ab Titers, Median (IQR), % ^§	Correlation Coefficient ρ	p-Value
Age		−0.028	0.5876 ^#
Male/female	−25.1 (−36.8 to −12.0)/−31.6 (−42.0 to −20.2)		0.0005 *
Body mass index, median (IQR), kg/m²		0.025	0.6274 ^#
Smoking (ever/never)	−28.4 (−39.7 to −15.5)/−30.3 (−40.7 to −19.0)		0.3051 *
Current smoker/ex-smoker	−31.7 (−40.6 to −18.3)/−27.4 (−40.1 to −16.1) ^§§		0.3853 *
	ex-smoker vs. never-smoker		0.2914 *
	current smoker vs. never-smoker		0.8809 *
Brinkman Index ^§§, ^§§§		−0.034	0.6990 ^#
Drinking	−29.1(−41.0 to −17.8)/−30.5(−39.1 to −18.1) ^§, ^§§		0.777 *
Allergy
Food	−29.4 (−37.1 to −16.5)/−29.4 (−39.9 to −18.6) ^§, ^§§		0.7821 *
Drug	−28.8 (−40.7 to −22.6)/−29.7 (−39.3 to −18.3) ^§, ^§§		0.7469 *
Allergic disease
Allergic rhinitis including pollinosis	−29.2 (−40.9 to −18.1)/−29.6 (−39.6 to −18.0) ^§, ^§§		0.8606 *
Bronchial asthma	−31.7 (−40.5 to −19.4)/−29.1 (−40.5 to −17.6) ^§, ^§§		0.5521 *
Skin allergy including atopic dermatitis	−30.3 (−44.6 to −25.1)/−29.1 (−39.7 to −17.6) ^§, ^§§		0.1677 *
Diabetes mellitus	−27.6 (−32.8 to −11.4)/−29.4 (−40.5 to −18.0) ^§, ^§§		0.3617 *
Hypertension	−24.0 (−32.1 to −12.3)/−29.7 (−40.8 to −18.0) ^§, ^§§		0.0679 *
Dyslipidemia	−31.7 (−39.2 to −22.8)/−29.3 (−40.5 to −17.7) ^§, ^§§		0.7178 *
Collagen disease	−27.0 (−48.6 to −19.1)/−29.6 (−40.3 to −17.9) ^§, ^§§		0.889 *

IQR = interquartile range. *: Mann–Whitney U test. ^#: Spearman’s rank correlation coefficient test. ^§: yes/no are shown. ^§§: unknown is excluded. ^§§§: ever-smoker only.