Figure 2.

Transmission electron microscopy image of the kidney biopsy (10 × 3000), showing a multivacuolized appearance of a podocyte (pod). Since the analysis in electron microscopy was carried out on a fragment of renal tissue recovered from paraffin (and not on a standard glutaraldehyde fixed preparation), the overall structural detail was poorly preserved, and glycosphingolipid deposits could not be directly visualized due to the extraction of the lipid components. This resulted in a multivacuolized appearance of the podocytes that, although not strictly diagnostic, was compatible with the diagnosis of Fabry disease.