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L-17 significantly and dose-dependently inhibited the firing activity of 5-HT neurons. (A): representative recording from a 5-HT neuron during L-17 (12 mg/kg) and WAY100135 (0.3 mg/kg) administration. (B): Summary effect of L-17 (0.1–12 mg/kg) and WAY100135 (0.3 mg/kg) on the spontaneous firing activity of 5-HT neurons of the DRN (data from 8 neurons from 7 rats).* p < 0.05 and *** p < 0.001, Bonferroni post-hoc test.
