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Box (median and 25–75th percentiles) and whiskers (5–95th percentiles) plot of isavuconazole trough concentrations (Ctrough) following administration of a loading dose of 200 mg every 8 h followed by a maintenance dose of 100 mg daily (A), 200 mg daily (B) or 300 mg daily (C). The dashed line identifies the isavuconazole toxicity threshold (Ctrough > 5.13 mg/L). A value of p < 0.001 was obtained in Kruskal-Wallis test.
