Table 2.

The study-specific input parameters in the OCCAT model.

OCCAT Parameter	Value
Formulation type	Buccal patch a
Drug dose	20 mg a
Film surface area	2.25 cm2 a
Oral transit model	Normal swallowing a
Saliva production rate (base value)	0.6 mL/min b
Fraction unbound in oral tissue (Fut)	0.21 c
Drug diffusivity through oral mucosa	7.21 × 10−7 cm2/s c

^a applies for the investigated buccal films; ^b optimized value [38]; ^c calculated using the software integrated equations.