Table 1.
Case studies of medicinal uses of cannabis for various ailments.
| Formulation and Route of Administration | Medical Condition | Cannabinoids Composition | Number of Subjects | Therapeutic Effects | Country | Reference |
|---|---|---|---|---|---|---|
| THC:CBD and THC extract were used | Cancer | 1:1:1 of THC:CBD, THC, and placebo | 177 patients | THC:CBD extract showed significant change as compared to the placebo. THC extract showed non-significant change. Induced nausea and vomiting. | Europe | [22] |
| CBD was used along with TRPA1 receptor, supplemented through diet | Inflammatory rheumatoid arthritis | Cannabinoids CBD and TRPA1 were used |
40 patients with long-standing rheumatoid arthritis | CBD showed anti-arthritis effects, it increased the intracellular calcium levels, reduces cell viability, and IL-6/IL-8/MMP-3 production of rheumatoid arthritis synovial fibroblasts (RASF) by activating TRPA1 and mitochondrial targets. | USA | [23] |
| Extracts of CBD and THC was inhaled or supplemented through diet | Epilepsy | 20% CBD and 1% THC were used | 74 patients, aged 1–18 years | Intractable epilepsy could be effectively treated with CBD-rich medicinal cannabis. There were just a few modest and occasional adverse effects mentioned. |
IL | [24] |
| Five different cannabis strains were used. Hybrid, Indica, Sativa, 3:1 CBD: THC, and 1:1 CBD: THC They were inhaled or supplemented through diet |
Headache, migraine, arthritis, and chronic pain | 3:1 ratio of CBD: THC and 1:1 ratio of CBD: THC were used | 2032 patients, 62.6% male (n = 1271), 37.3% females (n = 758) | Out of a total of 2032 people, cannabis was used to treat 21 ailments. Overall, 42.4% (n = 861) of people had pain syndromes, with chronic pain accounting for 29.4% (n = 598), arthritis accounting for 9.3% (n = 188), and headache accounting for 3.7% (n = 75). | UK | [25] |
| Hemp seed oil was consumed orally | Dermatitis and diseases of the skin | 30 mL (2tbsp) hemp seed oil and olive oil were used | 20 patients with atopic dermatitis | Hempseed oil consumption resulted in significant alterations in plasma lipid content and reduced clinical signs of atopic dermatitis as compared to olive oil. | USA | [26] |
CBD: Cannabidol; USA: United States of America; UK: United Kingdom; IL: Israel.