Figure 1.

Decynium 22 (D22) prevents amphetamine-induced conditioned place preference (CPP) in organic cation transporter 3 (OCT3) wild-type (+/+) male and female mice (A), and in female OCT3 knockout (−/−) mice (B). Male OCT3−/− mice do not develop significant CPP for amphetamine. n = 16 per group. Error bars indicate 95% confidence intervals (CI). Asterisks indicate mean values with 95% CI that do not include zero, representing statistically significant place preference (male and female OCT3+/+ and female OCT3−/− mice) or aversion (female OCT3−/− mice). * p < 0.05