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. 2021 Dec 9;22(24):13268. doi: 10.3390/ijms222413268

Figure 1.

Figure 1

Cardiotonic steroids interaction with Na,K-ATPase from pig and rat kidneys. ITC data for ouabain (A), digoxin (B), and marinobufagenin (C) binding to α1S−Na,K-ATPase in E2P—conformation and ouabain (D) binding to α1R-Na,K-ATPase in E2P—conformation. Titration curves (upper panel) and binding isotherms (lower panel) are shown for the Na,K-ATPase interaction with ouabain, digoxin and marinobufagenin at 37 °C, pH 7.4. Approximation of the isotherm was made using a model with one type of binding site (continuous line).