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. 2021 Dec 9;22(24):13268. doi: 10.3390/ijms222413268

Figure 4.

Figure 4

Superposition of cardiotonic steroids (CTSs) in α1S- and/or α1R-Na,K-ATPase docking models. CTSs’ positions in the CTSs-binding site of α1S and α1R-Na,K-ATPase for: (A)—ouabain, (B)—digoxin, (C)—marinobufagenin. Arg111 and Asp122 are colored in pink, CTSs interacting with α1R-Na,K-ATPase are colored red, with α1S-Na,K-ATPase colored in blue. (D)—Position of ouabain (orange), digoxin (red) and marinobufagenin (blue) in α1S-Na,K-ATPase. (E)—Position of ouabain (orange), digoxin (red) and marinobufagenin (blue) in α1R-Na,K-ATPase. Models based on the 4HYT structure of Na,K-ATPase. OBN—ouabain; DGX—digoxin; MBG—marinobufagenin.