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. 2021 Nov 29;7(4):74. doi: 10.3390/ncrna7040074

Figure 1.

Figure 1

The overall flow diagram is followed in the manuscript. To find out the transcription factors (TFs), especially IFR1-IFR5, IRF8, IRF9, STAT1-STAT4, STA5A, STAT6, NFKB1, NFKB2 and RELA/p65 (for justification for the choice please see Section 2.3) that might regulate the expression of the genes, we searched ChIPBase database. Similarly, the Interferome database was used to find out whether genes could be regulated by IFNs. Interacting partners of deregulated lncRNA obtained from NPInter v4.0 were further used for identifying the functional role of the genes/proteins in SARS-CoV-2 infection from BioGRID and PANTHER. To identify the common targets of TFs and deregulated lncRNA, we compared (shown as a double headed arrow) lncRNA interacting gene/protein and deregulated PCGs that were targets of common TFs. Finally the enrichment of the common targets of TFs and lncRNA using Enrichr for functional annotation of the co-regulated targets. IP addresses used are included. For details please see the text.