Table 2.
Equilibrium solubility after 24 h of two diclofenac salts in different release media. Experiments were conducted in triplicate (n = 3). The values are expressed as mean ± SD.
| Release Medium | pH | Temperature | Diclclofenac Sodium Salt [mg/mL] |
Diclofenac-DEA Salt [mg/mL] |
|---|---|---|---|---|
| PBS | 7.4 | 37.0 °C | 14.2 ± 0.3 | - |
| PBS + 1 g/L BSA | 7.4 | 37.0 °C | 15.2 ± 0.3 | - |
| PBS + 10 g/L BSA | 7.4 | 37.0 °C | 18.5 ± 0.2 | - |
| 40 mM Acetate buffer | 5.3 | 32.0 °C | 0.0314 ± 0.0008 | 0.0332 ± 0.0020 |
| 10 mM Phosphate buffer | 7.4 | 32.0 °C | 13.5 ± 0.8 | 10.2 ± 0.2 |