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. 2021 Dec 14;22(24):13435. doi: 10.3390/ijms222413435

Figure 1.

Figure 1

Metabolic switch during prostate tumorigenesis. In normal prostate cells, zinc ion impedes the TCA cycle to release the citrate for seminal fluid production, resulting in the low level of mitochondrial respiration activity (left panel). During the prostate tumor progression, Pca cells overexpress the glycolytic enzymes (including PKM2, MPC2, MCT, mtLDH, PDH, PDKs) to drive the pyruvate flux into the mitochondrial TCA cycle, leading to the high level of mitochondrial respiration activity (right panel).