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. 2021 Dec 18;22(24):13598. doi: 10.3390/ijms222413598

Figure 1.

Figure 1

Smad7 regulates the expression of the genes involved in pluripotency maintenance and self-renewal in ESCs. (A) Volcano plot showing the 1188 differentially expressed genes. Significantly differentially expressed genes in response to Smad7 KD (FDR < 0.05 and log2 fold change > 0.2) are indicated in red and blue. While 627 genes are upregulated, 561 genes are downregulated. The dashed line indicates the p-value significance threshold. Four biological replicates were used for this analysis. (B) Bar graph representing the enriched GO terms of biological processes in upregulated and downregulated genes after the KD of Smad7.