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. 2021 Nov 30;14(12):1247. doi: 10.3390/ph14121247

Scheme 1.

Scheme 1

Reagents and conditions: (i) Dimethylformamide dimethyl acetal, 100 °C, 1.5 h; (ii) appropriately substituted aniline, glacial acetic acid, reflux, 2 h; (iii) appropriate boronic acid, Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II), propylphosphonic anhydride, dioxane, 80 °C, 2 h.