Table 4.
Summary of evidence: time to first analgesic request (min) in adult patients.
| First Author, Year | Study Number | Participants Number (Mg/Control) | MD, SMD, RoM (95%CI) | Heterogeneity | Quality of Evidence (GRADE) |
|---|---|---|---|---|---|
| Shi 2021 | 11 | 613 (311/302) | MD, 329.99 (228.73,431.24) | I2 = 99%, p < 0.00001 | Low |
| Ma 2021 | 8 | 880 (440/440) | SMD, −3.0. (−4.32, −1.74) | I2 = 96.3%, p < 0.001 | Low |
| Li 2020 | 6 | 400 (200/200) | SMD, 4.96 (2.75, 7.17) | I2 = 98%, p < 0.00001 | Very low |
| Ng 2020 | 11 | 824 | MD, 143 (103, 183) | I2 = 99%, p < 0.001 | Low |
| Wang 2020 | 9 | 660 (330/330) | RoM, 1.23 (1.13, 1.33) | I2 = 96%, p < 0.00001 | Low |
| Zeng 2016 | 4 (Mg vs. placebo) | 229 (115/114) | MD, 3.59 (0.26, 6.93) | I2 = 99%, p < 0.00001 | Low |
| 3 (Mg vs. bupi) | 154 (77/77) | MD, −0.82 (−5.83, 4.20) | I2 = 99%, p < 0.00001 | ||
| 3 (Mg + bupi vs. bupi) | 154 (77/77) | MD, 6.25 (5.22, 7.29) | I2 = 69%, p = 0.04 | ||
| De Oliveira 2013 | 4 | 339 (161/178) | MD, 4.4 (−6.9, 15.9) | NR | CE |
| Albrecht 2013 | 4 | 298 (149/149) | MD, 7.2 (−1.9, 16.2) | I2 = 90%, p < 0.00001 | Low |
| Pascual-Ramirez 2013 | 10 | NR | MD, 85 SMD, 0.98 (0.51, 1.37) | I2 = 56%, p < 0.001 | Moderate |
Mg, magnesium group; Bupi, bupivacaine; MD, mean difference; SMD, standardized mean difference; RoM, ratio of means; CI, confidence interval; NR, not reported; CE, can’t evaluate.