Table 5.
Summary of evidence in pediatric patients.
| First Author, Year | Outcome | Study N | Participant N (Mg/Control) | RR, SMD, MD (95%CI) | Heterogeneity | Quality of Evidence (GRADE) |
|---|---|---|---|---|---|---|
| Kawakami 2018 | Incidence of rescue analgesia | 4 | 247 (117/130) | RR 0.45 (0.24, 0.86) | I2 = 62.5%, p = 0.046 | Very low |
| Cho 2017 | Pain score | |||||
| 15 min | 6 | 405 (203/202) | SMD −0.26 (−0.52, 0.00) | I2 = 40.36%, p = 0.1232 | Low | |
| 1 h | 9 | 615 (308/307) | SMD 0.05 (−0.70, 0.80) | I2 = 94.94%, p < 0.0001 | ||
| 24 h | 6 | 330 (165/165) | SMD −0.39 (−0.71, −0.07) | I2 = 50.56%, p = 0.0727 | ||
| Xie 2017 | Pain score | |||||
| (mCHEOPs) | Low | |||||
| 15 min | 2 | 160 (80/80) | MD 0.17 (−0.02, 0.35) | I2 = 0%, p = 0.77 | ||
| 1 h | 2 | 160 (80/80) | MD −0.59 (−3.11, 1.93) | I2 = 98%, p < 0.00001 | ||
| Incidence of rescue analgesia | 5 | 305 (153/152) | RR 0.53 (0.31, 0.91) | I2 = 69%, p = 0.01 | Low |
N, number; RR, risk ratio; SMD, standardized mean difference; MD, mean difference; CI, confidence interval; mCHEOPs, (modified-Children’s Hospital of Eastern Ontario Pain scale).