Table 2.
Treatment and clinical outcomes of patients with severe COVID-19.
| Variables | All Patients (n = 488) |
Younger Patients (n = 170) |
Older Patients (n = 318) |
p-Value |
|---|---|---|---|---|
| Treatment (%) | ||||
| Remdesivir | 244 (50.0) | 76 (44.7) | 168 (52.8) | 0.087 |
| Antibiotics | 294 (60.2) | 83 (48.8) | 211 (66.4) | <0.001 |
| Vasopressor | 61 (12.5) | 13 (7.6) | 48 (15.1) | 0.018 |
| CRRT | 24 (4.9) | 4 (2.4) | 20 (6.3) | 0.055 |
| Corticosteroid | 369 (75.6) | 125 (73.5) | 244 (76.7) | 0.433 |
| Oxygen supply device | ||||
| Nasal prong | 408 (83.6) | 151 (88.8) | 257 (80.8) | 0.023 |
| HFNC | 157 (32.2) | 47 (27.6) | 110 (34.6) | 0.118 |
| Invasive mechanical ventilation | 120 (24.6) | 40 (23.5) | 80 (25.2) | 0.691 |
| ECMO | 19 (3.9) | 9 (5.3) | 10 (3.1) | 0.242 |
| Tracheostomy (%) | 37 (7.6) | 10 (5.9) | 27 (8.5) | 0.300 |
| Outcomes | ||||
| In-hospital mortality (%) | 89 (18.2) | 8 (4.7) | 81 (25.5) | <0.001 |
| Length of hospital stay (days) | 16.0 (12.0–25.0) | 16.0 (12.0–22.0) | 17.0 (12.0–26.0) | 0.396 |
| Secondary infection | 143 (29.3) | 40 (23.5) | 103 (32.4) | 0.040 |
| DNR order | 81 (16.6) | 5 (2.9) | 76 (23.9) | <0.001 |
Data are presented as median and interquartile range or number (%), unless otherwise indicated. COVID-19: coronavirus disease 2019, CRRT: continuous renal replacement therapy, HFNC: high flow nasal cannula, ECMO: extracorporeal membrane oxygenation, DNR: do not resuscitate.