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. 2021 Dec 9;22(24):13260. doi: 10.3390/ijms222413260

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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MSD-Δt plots, diffusion area, and trajectory length of TrkA and p75^NTR in the control and PSEN1 mutant neurons. MSD curves show the diffusion modes of TrkA (A) and p75^NTR (B) in non-demented and PSEN1 mutant neurites. Graphs display the diffusion area of TrkA (C) and p75^NTR (D) in the control and PSEN1 mutant neurites. Histograms exhibit the trajectory length of TrkA (E) and p75^NTR (F) in control and PSEN1 mutant neurites. The data are expressed as mean ± SEM (*** p < 0.001). The number of trajectories of TrkA in control and PSEN1 mutant neurons = 1154; 1246, the number of trajectories of p75^NTR in control and PSEN1 mutant neurons = 1830; 2148. IPSC lines: Ctrl-1, Ctrl-2, Ctrl-3; fAD-1; fAD-2, fAD-3.