Table 2.
The biomarkers in adenovirus pneumonia patients with different severity of illness.
| Healthy Control (n = 20) | Mild (n = 82) | Severe (n = 58) | |
|---|---|---|---|
| Age (mean ± SD), years | 2.88 ± 1.54 | 2.74 ± 1.75 | 2.65 ± 2.17 |
| Blood routine | |||
| Leucocytes (1 × 109/L) | 7.90 (2.01) | 13.91 (6.89) **** | 6.43 (4.62) * |
| Increased | 0 | 43 (52%) | 3 (5%) |
| Decreased | 1 (5%) | 4 (5%) | 27 (47%) |
| Neutrophils (1 × 109/L) | 3.20 (1.57) | 8.35 (5.93) **** | 4.05 (3.36) |
| Increased | 0 | 40 (49%) | 7 (12%) |
| Decreased | 6 (30%) | 8 (10%) | 15 (26%) |
| Lymphocytes (1 × 109/L) | 3.92 (1.26) | 4.27 (2.08) | 1.91 (1.55) **** |
| Increased | 4 (20%) | 27 (33%) | 5 (9%) |
| 0 | 4 (5%) | 36 (62%) | |
| Blood biochemistry | |||
| Total protein (g/L) | 70.60 (3.46) | 67.36 (6.95) * | 60.96 (8.81) **** |
| Decreased | 1 (5%) | 22 (27%) | 41 (71%) |
| Albumin (g/L) | 46.91 (2.01) | 39.79 (6.10) **** | 29.19 (4.55) **** |
| Decreased | 0 | 37 (45%) | 56 (97%) |
| Total bilirubin (μmol/L) | 5.06 (2.09) | 4.52 (4.14) | 5.63 (7.16) |
| Increased | 0 | 1 (1%) | 1 (2%) |
| Decreased | 0 | 5 (6%) | 3 (5%) |
| γ-Glutamyl transpeptidase (U/L) | 10.24 (2.34) | 13.67 (9.21) ** | 47.53 (76.18) **** |
| Increased | 0 | 2 (2%) | 13 (22%) |
| Decreased | 7 (35%) | 12 (15%) | 3 (5%) |
| Alkaline phosphatase (U/L) | 220.65 (43.12) | 180.59 (57.66) *** | 102.09 (52.63) **** |
| Decreased | 1 (5%) | 9 (11%) | 38 (66%) |
| Lactate dehydrogenase (U/L) | 256.17 (36.51) | 349.09 (215.90) * | 1375.10(906.88) **** |
| Increased | 1 (5%) | 28 (34%) | 54 (93%) |
| Blood uric acid (mmol/L) | 272.21 (80.12) | 260.19 (83.92) | 213.16 (128.64) ** |
| Increased | 2 (10%) | 3 (4%) | 5 (9%) |
| Decreased | 1 (5%) | 0 | 5 (9%) |
| Coagulation function | |||
| D-dimer (μg/mL) | - | 0.68 (1.21) | 3.74 (5.68) **** |
| Increased | - | 4 (5%) | 26 (45%) |
| Infection biomarkers | |||
| Procalcitonin (ng/mL) | - | 1.20 (4.09) | 12.31 (23.93) **** |
| Increased | - | 34 (41%) | 46 (79%) |
| C-reactive protein (mg/L) | - | 28.93 (32.88) | 37.69 (41.97) |
| Increased | - | 45 (55%) | 47 (81%) |
| Radiological characteristics | |||
| Thickened lung texture | - | 81 (99%) | 58 (100%) |
| Mottled fuzzy shadows | - | 37 (45%) | 56 (97%) |
Data are presented by n (%) and mean (±SD). An increase mean over the upper limit of the normal range, and a decrease mean below the lower limit of the normal range. p < 0.05 (*), p < 0.01 (**), p < 0.001 (***), or p < 0.0001 (****), which mean healthy control vs. mild or healthy control vs. severe had statistical difference.