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. 2021 Dec 20;57(12):1387. doi: 10.3390/medicina57121387

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The effects of GGRT on lipid barrier elimination-induced atopic dermatitis lesions. The atopic dermatitis was induced by the elimination of the lipid barrier by SDS application. Isotonic sodium chloride solution, 5% ceramide, and 5% GGRT were administrated to lipid-eliminated mice skins for 3 days. (A) Photographs of skins were taken for macroscopic observation. (B) The fixed skins underwent H&E staining for histopathological examination. Bar size, 50 μm. (C–E) Skin score, TEWL, and pH were examined. *, p < 0.05 compared with LBE; #, p < 0.05 compared with C3A. Abbreviations: Ctrl, healthy control group; LBE, normal saline-treated group after lipid barrier elimination; C3A, 5% ceramide 3B treated group after lipid barrier elimination; GGRT, 5% GGRT extract treated group after lipid barrier elimination; TEWL, trans-epidermal water loss; H&E, hematoxylin and eosin; EP, epithelium.