Table 1.
Outcomes of case reports affected by multidrug resistant fungal keratitis.
| Ref. (Year) Citation | Pathogens | Initial VA | Antifungal Drugs | Surgery | Outcome |
|---|---|---|---|---|---|
| Sponsel (2002) [30] | F. solani | Not mentioned | AMB-intravenous, topical KTC-topical NAT-topical POS-PO, topical |
PK | VA: 6/30 |
| Guarro (2003) [53] | F. polyphialidicum | 1/200 | AMB-topical | Corneal transplantation | VA: 20/40 (improved) |
| Tu (2007) [54] | F. solani | HM | AMB-IVI, topical FLC-PO ITC-PO NAT-topical POS-PO VRC-intravenous, IVI, PO |
PK for 3 times | VA: CF (improved) |
| Fusarium sp. | Not mentioned | AMB-topical FLC-PO NAT-topical VRC-PO, topical POS-PO, topical |
PK for 2 times | Resolution of inflammation | |
| Fusarium sp. | Not mentioned | AMB-AC injection, topical CYA-topical FLC-PO NAT-topical POS-PO VRC-IVI, PO, topical |
PK, penetrating patch graft | Poor vision, awaiting repeat corneal transplantation | |
| Proença-Pina (2010) [55] | F. solani | HM | AMB-AC irrigation, topical VRC-PO, topical |
PK | VA: 20/50 (improved) |
| Edelstein (2012) [56] | F. solani | HM | AMB-ICI, IVI, topical FLC-PO ITC-PO NAT-topical POS-PO VRC-PO, topical |
PK for 2 times, pars plana vitrectomies, enucleation | Enucleation |
| Antequera (2015) [31] | F. solani | - | AMB-intravenous CAS-intravenous VRC-intravenous, PO, topical |
Enucleation | Enucleation |
| Sara (2016) [12] | F. solani | 6/12 | AMB-IVI NAT-topical VRC-IVI, PO, topical |
PK, enucleation | Enucleation |
AC: Anterior chamber; AMB: Amphotericin B; CAS: Caspofungin; CF: Counting fingers; CYA: Cyclosporine A; FLC: Fluconazole; HM: Hand movement; ICI: Intracameral injection; ITC: Itraconazole; IVI: Intravitreal injection; KTC: Ketoconazole; NAT: Natamycin; PK: Penetrating keratoplasty; PO: oral; POS: Posaconazole; VA: Visual acuity; VRC: Voriconazole.