Table 5.
Potential protein targets of (+)-cedrol identified by PharmMapper.
| Rank | PDB ID | Target Name | Fit Score | Rank | PDB ID | Target Name | Fit Score |
|---|---|---|---|---|---|---|---|
| 1 | 1REU | BMP2 | 1 | 11 | 2PIR | Androgen receptor | 0.8213 |
| 2 | 1P49 | Steroid sulfatase | 1 | 12 | 3BL1 | CA2 | 0.8032 |
| 3 | 1J96 | AKR1C2 | 1 | 13 | 3CJG | VEGFR2 | 0.7553 |
| 4 | 1E7E | Serum albumin | 1 | 14 | 2OF0 | β-Secretase 1 | 0.75 |
| 5 | 1L6L | Apo A-II | 1 | 15 | 1SQN | Progesterone receptor | 0.75 |
| 6 | 1W8L | PPIase A | 0.9633 | 16 | 2G01 | JNK1 | 0.7472 |
| 7 | 2PG2 | KIF11 | 0.9482 | 17 | 1ZXC | ADAM 17 | 0.7442 |
| 8 | 2C3I | Pim-1 | 0.8963 | 18 | 1SHL | Caspase-7 | 0.7399 |
| 9 | 1J78 | DBP | 0.8598 | 19 | 1P0P | Cholinesterase | 0.7331 |
| 10 | 3EQM | P450 19A1 | 0.8397 | 20 | 1S95 | PPP5 | 0.7326 |
Abbreviations: ADAM 17, metalloprotease 17; AKR1C2, aldo-keto reductase family 1 member C2 (bile acid binding protein); Apo A-II, apolipoprotein A-II; BMP2, bone morphogenetic protein 2; CA2, carbonic anhydrase 2; DBP, vitamin D-binding protein; KIF11, kinesin-like protein; JNK1, c-Jun N-terminal kinase 1; P450 19A1, cytochrome P450 19A1; Pim-1, proto-oncogene serine/threonine-protein kinase; PPIase A, peptidyl-prolyl cis-trans isomerase A; PPP5, serine/threonine-protein phosphatase 5; VEGFR2, vascular endothelial growth factor receptor 2.