Table 3.
Effects of APEE Pre-treatment on lung W/D ratio, lung NO, Serum TAC, and MPO activity in LPS-induced acute lung injury in mice.
| Lung W/D Ratio | Lung NO Content (nmol/g Tissue) |
Serum TAC (Mm/L) | Lung MPO Activity (µM/min/g Tissue) | |
|---|---|---|---|---|
| Control saline | 7.6 ± 1.1 | 12.6 ± 0.85 | 1.92 ± 0.12 | 2.81 ± 0.29 |
| LPS | 11.5 ± 0.85 a | 23.6 ± 1.6 a | 0.53 ± 0.085 a | 11.36 ± 0.77 a |
| APEE 200 | 9.5 ± 0.94 b | 17.8 ± 1.3 b | 0.9 ± 0.06 b | 6.8 ± 0.84 b |
| APEE 250 | 7.8 ± 1.01 bc | 13.1 ± 1.1 bc | 1.89 ± 0.15 bcd | 3.01 ± 0.29 bcd |
| APEE 250 | 8.5 ± 0.81 b | 15 ± 1.5 b | 1.5 ± 0.18 b | 3.85 ± 0.36 b |
Acute lung injury was urged by I.P. injection of LPS (10 mg/kg). APEE 200, 250, and 300 were given I.P. 30 min before LPS injection. Results were expressed as mean ± SD (n = 10/group). The experiments were performed in three independent replicates. Significant difference vs. a respective control, b respective LPS group, c respective APEE 200 group, d respective APEE 300 group each at p < 0.05.