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. 2021 Dec 7;22(24):13188. doi: 10.3390/ijms222413188

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Univariate ROC analysis of the significantly changed metabolites. (A) ROC plots for four representative metabolites (Thiamine, L-tyrosine, L-Tryptophan and Indole) that increase in benfotiamine treatment serum samples (p value < 0.05). (B) ROC plots for three representative metabolites (O ureido-D-Seine, carboxymethyl-lysine) that decrease in benfotiamine treatment serum samples (p value < 0.05). Red boxes represent placebo samples, green boxes are BFT treated samples and yellow diamond denotes the median value for log₂ (fold change).