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. 2021 Dec 5;13(12):2087. doi: 10.3390/pharmaceutics13122087

Figure 7.

Figure 7

Microscopic pictures of hematoxylin and eosin (H&E)-stained hepatic sections of the different groups following the pretreatment regimen. Low magnification x: 100 bar 100 µm and high magnification Xx: 400 bar 50 µm. CV, central vein; PA, portal area. In the positive control: focal areas of necrosis (asterisks); apoptosis (arrowheads); vacuolization (black arrows); hydropic degeneration (yellow arrows); hepatocytes with infiltration of a few leukocytic cells (red arrows). In the DSN-pretreated group: leukocytic cell infiltration close to the central vein (black arrow); portal inflammation (black arrow); hydropic degeneration in hepatocytes (arrowheads). In the DSN–PLX188-NC-pretreated group: lobular inflammation (yellow arrows); hydropic degeneration (arrowheads). In the DSN–PLX188–CS-NC-pretreated group: leukocytic cell infiltration in portal area (black arrow).