Table 1.
Particle size analysis of the prepared NC dispersions.
| Stabilizer | Concentration (% w/v) |
Size (nm) | PDI |
|---|---|---|---|
| PVP K25 | 0.1 | 578.53 ± 16.98 | 0.32 ± 0.06 |
| 0.15 | 401.20 ± 16.48 * | 0.25 ± 0.02 | |
| 0.3 | 466.47 ± 11.34 *# | 0.30 ± 0.03 | |
| 0.6 | 662.57 ± 22.70 *#@ | 0.55 ± 0.02 | |
| PLX188 | 0.1 | 401.66 ± 54.50 | 0.42 ± 0.11 |
| 0.15 | 350.20 ± 1.79 * | 0.24 ± 0.01 | |
| 0.3 | 353.30 ± 2.50 * | 0.22 ± 0.01 | |
| 0.6 | 528.03 ± 3.53 *#@ | 0.36 ± 0.03 | |
| SDS | 0.1 | 968.03 ± 66.70 | 0.49 ± 0.05 |
| 0.15 | 828.27 ± 54.36 * | 0.42 ± 0.03 | |
| 0.3 | 527.33 ± 10.01 *# | 0.40 ± 0.05 | |
| 0.6 | 832.09 ± 21.87 *@ | 0.22 ± 0.05 | |
| CS/PLX188 | 0.02/0.15 | 443.13 ± 6.05 $ | 0.35 ± 0.02 |
| 0.04/0.15 | 368.93 ± 0.47 * | 0.23 ± 0.01 | |
| 0.06/0.15 | 453.17± 11.71 #$ | 0.25 ± 0.04 |
Data are presented as the mean ± SD (n = 3). The statistical analysis was performed at p < 0.05. *, #, $, and @ indicate significant differences. Regarding PVP K25, SDS, and PLX188: * vs. 0.1% w/v; # vs. 0.15% w/v; @ vs. 0.3% w/v. Regarding CS/PLX188 combinations: * vs. 0.02/0.15 (% w/v); # vs. 0.04%/0.15 (% w/v); $ vs. 0.15% w/v PLX188 alone. PVP K25, poly vinyl pyrrolidone K25; PLX188, poloxamer 188; SDS, sodium dodecyl sulfate; CS, chitosan; PDI, poly dispersity index.