Table 3.
Lyophilization effects on the size and the size distribution of the selected NCs.
| Formula | Size (nm) | PDI |
|---|---|---|
| DSN–PLX188 NCs | ||
| Before lyophilization | 350.20 ± 1.79 | 0.24 ± 0.01 |
| After lyophilization with 1% w/v mannitol | 349.43 ± 5.75 | 0.24 ± 0.02 |
| After lyophilization without 1% w/v mannitol | 487.53 ± 26.65 *# | 0.54 ± 0.02 *# |
| DSN–PLX188–CS NCs | ||
| Before lyophilization | 368.93 ± 0.47 | 0.21 ± 0.03 |
| After lyophilization with 1% w/v mannitol | 360.36 ± 7.07 | 0.24 ± 0.03 |
| After lyophilization without 1% w/v mannitol | 408.50 ± 12.27 *# | 0.386 ± 0.03 *# |
Data are presented as the mean ± SD. The statistical analysis was performed at p < 0.05. *, and # indicate significant differences. * vs. formula before lyophilization; # vs. formula after lyophilization with 1% w/v mannitol.